| Date | Location | Result | |
| 11/26/21 | Vermillion, SD | South Dakota 3, South Dakota St. 2 (20-25,25-18,25-20,24-26,18-16) | Box score |
| 11/25/21 | Vermillion, S.D. | South Dakota St. 3, Denver 2 (19-25,25-23,21-25,25-23,15-10) | Box score |
| 11/20/21 | Grand Forks, N.D. | South Dakota St. 3, North Dakota 0 (25-23,25-21,25-16) | Box score |
| 11/18/21 | Fargo, ND | South Dakota St. 3, North Dakota St. 1 (26-24,21-25,25-19,25-19) | Box score |
| 11/13/21 | Brookings, SD | Denver 3, South Dakota St. 0 (25-22,25-22,25-21) | Box score |
| 11/11/21 | Brookings, SD | Omaha 3, South Dakota St. 0 (25-15,25-17,25-15) | Box score |
| 11/07/21 | Macomb, IL | South Dakota St. 3, Western Ill. 2 (25-18,31-29,24-26,22-25,15-10) | Box score |
| 11/05/21 | Saint Paul, MN | South Dakota St. 3, St. Thomas (MN) 1 (21-25,25-15,27-25,25-15) | Box score |
| 10/30/21 | Brookings, SD | South Dakota St. 3, Kansas City 1 (25-23,25-20,18-25,25-21) | Box score |
| 10/28/21 | Brookings, SD | South Dakota St. 3, Oral Roberts 2 (25-19,8-25,21-25,31-29,16-14) | Box score |
| 10/22/21 | Brookings, SD | South Dakota 3, South Dakota St. 1 (25-14,14-25,25-15,25-22) | Box score |
| 10/16/21 | Omaha, NE | Omaha 3, South Dakota St. 0 (25-8,25-18,25-18) | Box score |
| 10/14/21 | Denver, CO | Denver 3, South Dakota St. 0 (25-11,25-22,25-19) | Box score |
| 10/12/21 | Brookings, SD | South Dakota St. 3, North Dakota St. 1 (25-18,18-25,25-22,25-21) | Box score |
| 10/09/21 | Brookings, SD | South Dakota St. 3, St. Thomas (MN) 0 (25-12,25-11,25-18) | Box score |
| 10/07/21 | Brookings, SD | South Dakota St. 3, Western Ill. 1 (25-23,25-23,21-25,25-17) | Box score |
| 10/02/21 | Tulsa, OK | Oral Roberts 3, South Dakota St. 2 (25-18,19-25,13-25,25-15,15-11) | Box score |
| 09/30/21 | Kansas City, MO | Kansas City 3, South Dakota St. 0 (25-12,25-21,25-21) | Box score |
| 09/28/21 | Brookings, SD | South Dakota St. 3, North Dakota 1 (24-26,25-18,25-22,25-17) | Box score |
| 09/24/21 | Vermillion, SD | South Dakota 3, South Dakota St. 1 (19-25,25-12,25-22,25-18) | Box score |
| 09/18/21 | Brookings, SD | Drake 3, South Dakota St. 0 (25-13,25-13,25-23) | Box score |
| 09/17/21 | Brookings, SD | South Dakota St. 3, Idaho 0 (25-19,25-11,25-16) | Box score |
| 09/17/21 | Brookings, SD | South Dakota St. 3, Southeastern La. 2 (25-19,20-25,21-25,25-14,15-9) | Box score |
| 09/11/21 | Toledo, OH | South Dakota St. 3, Valparaiso 0 (25-14,25-18,25-23) | Box score |
| 09/11/21 | Toledo, OH | South Dakota St. 3, Youngstown St. 2 (23-25,25-20,25-21,22-25,15-12) | Box score |
| 09/10/21 | Toledo, OH | Toledo 3, South Dakota St. 2 (23-25,25-15,23-25,25-22,15-12) | Box score |
| 09/04/21 | Brookings, SD | South Dakota St. 3, California Baptist 0 (25-19,25-22,25-16) | Box score |
| 09/03/21 | Brookings, SD | South Dakota St. 3, Montana 0 (25-16,25-22,25-20) | Box score |
| 08/28/21 | South Dakota St. 3, McNeese 0 (25-20,25-15,25-22) | Box score | |
| 08/27/21 | Denton, TX | North Texas 3, South Dakota St. 1 (25-22,21-25,25-17,25-17) | Box score |
| 08/27/21 | Denton, TX | South Dakota St. 3, Grambling 0 (25-12,25-9,25-15) | Box score |